Changing Patterns of Diagnosis and Survival in Transthyretin Cardiac Amyloidosis: A Multicenter Cohort Study.

ABSTRACT:

Background

Diagnostic rates of transthyretin cardiac amyloidosis have increased due to growing awareness, noninvasive diagnoses, and treatments that improve morbidity and mortality. We sought to investigate real-world trends in baseline characteristics and survival in the United States.

Methods

Patient-level data at 5 cardiac amyloid referral centers were used, and mortality (defined as death or surgical heart failure therapies) was compared by eras (pre-2010, 2010-2013, 2014-2017, and 2018-2021) and National Amyloidosis Center (NAC) stage.

Results

Among 1165 subjects, diagnosis of transthyretin cardiac amyloidosis in a more recent era was associated with older age, white race, wild-type disease, and tafamidis treatment (P<0.001). NAC stage was similar (P

SUBMITTER: Sperry BW 

PROVIDER: S-EPMC12748506 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature