DNA Methylation Algorithms of Aging and Incident Cardiovascular Disease: A Prospective Cohort Study.

ABSTRACT:

Background

While DNA methylation (DNAm)-based algorithms of aging show promise for predicting age-related diseases, their comparative utility for incident cardiovascular disease (CVD) remains underexplored. We aimed to systematically compare 13 DNAm algorithms in relation to CVD risk in older adults.

Methods

This prospective cohort study included 2112 participants from the US HRS (Health and Retirement Study) with baseline DNAm data (2016) and 6-year follow-up. DNAm profiling was performed using the Infinium MethylationEPIC BeadChip kit (EPIC, Illumina, San Diego, CA). Thirteen widely used DNAm algorithms of aging were evaluated. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% CIs per 1-SD increase in risk scores for incident CVD, including

SUBMITTER: Cui X 

PROVIDER: S-EPMC12748520 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature