A novel method of quantifying retinal vascular tortuosity in retinopathy of prematurity.

ABSTRACT: This study evaluated the diagnostic performance of a novel vessel tracing software that quantifies retinal vessel tortuosity in premature infants for assessing retinopathy of prematurity (ROP). Seventy-three retinal images of premature infants were subjectively classified as having "Normal" or "Abnormal" tortuosity based on arterial tortuosity of the posterior retina by seven clinicians. The software then semi-automatically traced the same arteries within circular regions of interest centered at the optic disc, with radii ranging from 2 to 20x the disc diameters. Vessel tortuosity was defined as the sum of external angles at vessel bend points. Tortuosity was significantly greater in Abnormal images within regions exceeding 4-disc diameters (p < 0.05). Diagnostic accuracy improved with lar

SUBMITTER: Zhou HP 

PROVIDER: S-EPMC12748533 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature