Performance and clinical relevance of continuous glucose monitoring during early brain injury in subarachnoid hemorrhage.

ABSTRACT: Glycemic dysregulation after spontaneous subarachnoid hemorrhage (SAH) has been associated with poor outcomes, potentially through glucose-driven neurotoxicity. This study assessed the performance of Continuous Glucose Monitoring (CGM) during the Early Brain Injury (EBI) phase and explored associations between glucose metrics, functional outcome, and serum Neurofilament Light Chain (NFL) levels as a surrogate biomarker of neuroaxonal injury. In this prospective single-center study, 65 non-diabetic SAH patients admitted within 24 h of onset underwent 72-hour CGM and finger-prick glucose testing every six hours. CGM agreement with finger-prick was evaluated through Median Absolute Relative Difference (MARD) and Clarke Error Grid. Multivariate models assessed associations between glucose metr

SUBMITTER: Santana D 

PROVIDER: S-EPMC12748534 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature