The downregulation of RIZ1 activates the AKT/mTOR in pregnant women with obesity.

ABSTRACT: Riz1 knockout mice demonstrated obesity with activation of the V-Akt murine thymoma viral oncogene homolog (PKB) (AKT)/mechanistic target of rapamycin (mTOR) pathway. Whether the decrease in RIZ1 and the activation of AKT/mTOR exist in pregnant women with obesity is still unknown. This study examined the association between RIZ1, AKT/mTOR, and obesity through a prospective methodological approach in pregnant women. A total of 260 pregnant women, including 71 lean, 75 normal weight, 56 overweight, and 58 obesity, were enrolled. Pregnant women with obesity had higher baby weights and cesarean section rates, exhibiting the highest rate of irregular meal habits with high-protein and low-vegetable/fruit dietary patterns. The plasma concentration of C0-C5 carnitine decreased gradually from the l

SUBMITTER: Xie X 

PROVIDER: S-EPMC12748553 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature