Distinct mechanisms of transcriptomic habituation to repeated stress in the mouse hippocampus.

ABSTRACT: Chronic stress is a risk factor for neuropsychiatric disorders, making the ability to adapt to repeated stress a crucial determinant of mental health. It remains unclear whether repeated stress exposure leads to habituation or new adaptive responses. Here, we investigated how the transcriptomic response to acute restraint stress changes - in the mouse ventral hippocampus - with repeated exposure. Using bulk RNA-seq across multiple timepoints, we observed widespread transcriptional habituation: stress-induced gene expression was blunted without the emergence of new response profiles or changes in baseline gene expression. Temporally resolved single-nucleus multi-omic profiling (RNA and chromatin accessibility) confirmed that the transcriptional habituation occurs across cell types, revealin

SUBMITTER: Waag R 

PROVIDER: S-EPMC12748579 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature