Enhancing antiretroviral delivery to secondary lymph nodes by targeting CD169 + macrophages with HIV-mimicking nanoparticles.

ABSTRACT: Despite significant progress in combinatorial antiretroviral therapy, people living with HIV remain susceptible to co-morbidities and increased risks of mortality. Chronic inflammation and immune activation are correlated with viral persistence in reservoir sites such as secondary lymph nodes and are postulated to be a driver of exaggerated risk of HIV-associated co-morbidities. Previous studies have revealed that low and heterogeneous penetration of antiretrovirals (ARVs) in lymph nodes can contribute to viral persistence. In addition, sub-optimal adherence to daily oral ARVs can lead to the development of antiviral resistance and viral rebound from these sanctuary sites. To overcome these deficiencies, we developed membrane-wrapped poly-lactic acid nanoparticles expressing the gangliosid

SUBMITTER: Fofana J 

PROVIDER: S-EPMC12748623 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature