Potential glutamine metabolism-related biomarkers were identified in osteoarthritis by bioinformatics.

ABSTRACT: Osteoarthritis (OA) is a prevalent joint disorder. It is of great importance to identify efficacious therapeutic targets and biomarkers for the treatment of inflammatory joint diseases and the effective management of their condition. Glutamine metabolism is pivotal in regulating chondrocyte function, maintaining bone homeostasis and modulating the inflammatory response. This study aimed to identify glutamine metabolism-related genes that may serve as potential biomarkers for OA. The OA transcriptome dataset and the glutamine metabolism-related genes were obtained. Subsequently, consistency clustering was employed to differentiate between different disease types for the glutamine metabolism-related genes in the OA transcriptome dataset. Furthermore, differential expression analysis was cond

SUBMITTER: Li D 

PROVIDER: S-EPMC12748631 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature