Multi-omics analysis reveals shared diagnostic and therapeutic targets in endometriosis and recurrent implantation failure.

ABSTRACT: Endometrial receptivity is essential for successful pregnancy, and endometriosis is widely recognized as a disruptor of this process. Poor endometrial receptivity is also a key factor contributing to recurrent implantation failure. Although some molecular mechanisms related to endometrial receptivity have been identified, their specific roles in endometriosis and recurrent implantation failure remain unclear. This study aimed to elucidate the shared molecular mechanisms affecting endometrial receptivity in endometriosis and recurrent implantation failure using multi-omics data analysis. We sourced datasets from the NCBI GEO database and employed weighted gene co-expression network analysis to identify gene modules associated with these conditions, followed by gene ontology (GO) and Kyoto E

SUBMITTER: Yu J 

PROVIDER: S-EPMC12748698 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature