Circ005699 regulates ox-LDL-induced vascular endothelial cell proliferation, autophagy and inflammation by sponging miR-636 and interacting with FTO.

ABSTRACT: Atherosclerosis (AS) is a chronic vascular disorder driven by endothelial dysfunction and inflammation, yet the roles of circular RNAs (circRNAs) in this process remain incompletely defined. Here, we identified circ0005699 as a significantly upregulated circRNA (fold change > 2, P < 0.05) in ox-LDL-treated macrophages and endothelial cells and confirmed its circular structure and stability by divergent PCR, RNase R resistance, and actinomycin D assays. qRT‒PCR analysis revealed elevated circ0005699 expression in serum from AS patients compared with that in serum from matched controls (n = 10 pairs, P < 0.01). Functional studies revealed that circ0005699 knockdown enhanced endothelial proliferation and tube formation, whereas overexpression suppressed angiogenesis. Mechanistically, circ0005

SUBMITTER: Chen W 

PROVIDER: S-EPMC12748728 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature