Novel anti-prion compounds screening in prion-infected cell culture model combined with surface plasmon resonance analysis.

ABSTRACT: Prions are misfolded proteins (PrP^Sc) capable of inducing the same conformational change in normal prion proteins (PrP^C). These aberrant proteins are responsible for neurodegenerative diseases in animals and humans, for which no effective treatments currently exist. At present, preventive diagnostic screening remains the only viable intervention. Our research has focused on screening compound libraries to identify small molecules capable of blocking PrP^Sc formation using a prion-infected cell culture model. Over the past several years, we have identified and assembled a set of compounds with diverse chemotypes that inhibit prion activity in human prion-infected cells while maintaining acceptable toxicity profiles, without affecting cell proliferation and mo

SUBMITTER: Hazekawa M 

PROVIDER: S-EPMC12748794 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature