Age disparities in adverse reactions of drugs used in pain therapies in Switzerland.

ABSTRACT: Pain therapies are prescribed to a significant proportion of the population but also associated with adverse drug reactions (ADRs). The prescription of pain therapies requires careful consideration of their safety profiles in the context of patient-specific characteristics, such as age-specific vulnerabilities, which are, however, still understudied so far. The aim of this study was to describe ADRs reported for drugs used in pain therapies and investigate age disparities. We conducted a descriptive comparative analysis of individual case safety reports (ICSRs) of drugs used in pain therapies from the global ADR database VigiBase between September 29, 1991, and December 31, 2022, from Switzerland. Comparisons were drawn between younger and older adults (18-74 years vs. 75 + years). Disprop

SUBMITTER: Gasparovic L 

PROVIDER: S-EPMC12748878 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature