Lactylation-related gene signatures define immune heterogeneity and provide diagnostic biomarkers for periodontitis.

ABSTRACT: Periodontitis is a prevalent inflammatory disease characterized by immune dysregulation and tissue destruction, yet the molecular mechanisms linking metabolic epigenetic modifications and immune responses remain insufficiently understood. Recent evidence suggests protein lactylation plays a pivotal role in shaping immune landscapes in chronic inflammation, but its relevance in periodontitis is largely unexplored. We systematically analyzed microarray-based bulk gene expression datasets from gingival tissues and single-cell RNA sequencing (scRNA-seq) data derived from peripheral blood mononuclear cells of periodontitis patients and healthy controls. Differentially expressed lactylation-associated genes (DE-LACRGs) were identified using established bioinformatics workflows. Immune infiltrati

SUBMITTER: Zhu Y 

PROVIDER: S-EPMC12748881 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature