Pin1 as a Central Modulator of Wnt/β-Catenin Signaling in Pulmonary Fibrosis: Interplay with EBV-LMP1 and Therapeutic Implications.

ABSTRACT:

Background

Pulmonary fibrosis (PF) is characterized by dysregulated signaling, with the Wnt/β-catenin pathway playing a critical role. Pin1, a peptidyl-prolyl isomerase, is implicated in post-translational modifications and cellular signaling.

Objectives

This study explores the expression, localization, and functional role of Pin1 in regulating Wnt/β-catenin signaling in human lung fibroblasts (MRC-5 cells). These cells, derived from normal lung tissue, are commonly used to model fibrotic processes due to their ability to mimic fibroblast behavior in PF. Importantly, we report the first demonstration of Epstein-Barr virus (EBV) latent membrane protein 1 (LMP1)-mediated Pin1 activation in the context of PF. Notably, we demonstrate that EBV-LMP1 activates Pin1 and amplifies Wn

SUBMITTER: Jiao X 

PROVIDER: S-EPMC12748884 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature