A novel zinc finger protein gene signature for prognostic prediction, tumor microenvironment characterization, and therapeutic response in uterine corpus endometrial carcinoma.

ABSTRACT: Zinc finger protein (ZNF) family is the largest transcription factor family in the human genome. Studies have shown that the aberrant expression of ZNF had a potential role in tumorigenesis. However, the role of ZNF family genes in uterine corpus endometrial carcinoma (UCEC) is still not systematically understood. Transcriptomic profiles and clinical data of endometrial carcinoma were obtained from TCGA and GEO databases. Based on differentially expressed ZNF genes, unsupervised clustering was employed to stratify samples into distinct subtypes, followed by enrichment analysis to compare gene expression patterns and pathway alterations across subgroups. Patients were subsequently divided into training and test cohorts, through univariate COX regression, LASSO (least absolute shrinkage and

SUBMITTER: Lv H 

PROVIDER: S-EPMC12748908 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature