Decreased Fc fucosylation aligns with enhanced RSV-specific antibody functionality in adults compared to young children.

ABSTRACT:

Background

Respiratory syncytial virus (RSV) is a major cause of severe respiratory tract infections in infants and older adults. While RSV vaccines have recently been approved for older adults and pregnant women, and newborns can be protected through monoclonal antibody immunization, vaccine development for infants remains challenging. Understanding immunological differences between target groups is essential for improving vaccination strategies, but no clear correlates of protection have been identified yet. Antibody Fc-mediated effector functions may play an important role. Here, we aim to delineate RSV-specific antibody features underlying differences in antibody functionality between children and adults.

Methods

In an observational cohort of 24-month old children and ad

SUBMITTER: Lakerveld AJ 

PROVIDER: S-EPMC12748917 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature