Spatial Transcriptomics Unveils Landscape of Resistance to Concurrent Chemo-Radiotherapy in Hypopharyngeal Squamous Cell Carcinoma: The Role of SPP1⁺ Macrophages.

ABSTRACT:

Background

Hypopharyngeal squamous cell carcinoma (SCC) is an aggressive malignancy with a poor prognosis, particularly in advanced stages. Concurrent chemoradiotherapy (CCRT) is frequently employed to preserve the larynx, but resistance to CCRT remains a significant clinical challenge. Understanding the tumor microenvironment (TME) in CCRT-resistant cases is crucial for identifying predictive biomarkers and developing targeted therapies to improve outcomes.

Methods

This study analyzed tissue samples from patients with advanced hypopharyngeal SCC who were either resistant to CCRT or had not received CCRT. Spatial transcriptomics (ST) was used to explore the spatial molecular signatures within the TME of these samples, focusing on the interactions between immune cells and mal

SUBMITTER: Ohn J 

PROVIDER: S-EPMC12748936 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature