Cellular and molecular associations with intrinsic brain organization.

ABSTRACT: Understanding how cellular and molecular architecture underpins the large-scale organization of human brain function is a central challenge in neuroscience. By integrating transcriptomic (microarray and single-nucleus RNA-sequencing), molecular imaging, and neuroimaging datasets, we observe spatial correspondences indicating that the distributions of diverse cell types, neurotransmitter systems, and mitochondrial phenotypes align with intrinsic connectivity networks (ICNs). These associations extend beyond local correspondence to reflect network-level structure: inter-ICN similarity networks derived from cellular and molecular profiles recapitulate static and dynamic patterns of functional network connectivity (FNC), mirroring canonical functional domains. Mediation analyses reveal that sp

SUBMITTER: Feng G 

PROVIDER: S-EPMC12748960 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature