Pilot study on exercise-induced placental transcriptomic changes and oxidative stress reduction in gestational diabetes mellitus.

ABSTRACT: Gestational diabetes mellitus (GDM) is a common pregnancy complication associated with adverse maternal and neonatal outcomes, characterised by inflammation and oxidative stress. While exercise interventions have been shown to alleviate some of these issues, the underlying molecular mechanisms, particularly in the placenta, remain poorly understood. This study investigates the impact of exercise on maternal immune function, oxidative stress, placental gene expression, and neonatal outcomes in GDM pregnancies. This pilot study involved 12 pregnant women, six with GDM and six with normal pregnancies. Participants were divided into four groups: normal pregnancies with exercise (NCE) or without exercise (NC), and GDM pregnancies with exercise (GDME) or without exercise (GDM). The exercise inte

SUBMITTER: Li X 

PROVIDER: S-EPMC12749014 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature