Development of a nano antibiotic paste for lesion sterilization and tissue repair technique in pediatric dentistry.

ABSTRACT: This is an in vitro study aimed to develop a nano-antibiotic paste containing chloramphenicol, tetracycline, and silver and zinc oxide nanoparticles, evaluating its microbiological efficacy against four bacterial strains, determining its minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) against a commercial CTZ paste. Silver and zinc oxide nanoparticles (1 × 10^- 2 M) were synthesized and characterized by UV-Vis and DLS. A paste of tetracycline and chloramphenicol was prepared to a known concentration (10%), adding the synthesized nanoparticles and reducing the antibiotic percentage from the original proportions (- 4%). The commercial CTZ paste was then prepared following the manufacturer's instructions (13% concentration). Microdilution method a

SUBMITTER: Guzman Uribe D 

PROVIDER: S-EPMC12749045 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature