Exploratory evidence of mitigated immune imprinting following concomitant COVID-19 and influenza vaccination.

ABSTRACT: Concomitant administration of coronavirus disease (COVID-19) and influenza vaccination schedules has been widely adopted. However, long-term data on the immunological impact, particularly on variant-specific responses, remain limited. In this 10-month prospective study, 80 participants (40 per group) received either a concomitant bivalent COVID-19 mRNA booster and quadrivalent influenza vaccination (Group C) or separate vaccinations (Group S) at least 4 weeks apart. Immunogenicity was evaluated using an anti-S IgG electrochemiluminescence immunoassay, anti- receptor-binding domain (RBD) IgG enzyme-linked immunosorbent assay, focus reduction neutralisation test (FRNT), and hemagglutination-inhibition assay. Both Groups C and S elicited robust immune responses for up to 10 months with no imm

SUBMITTER: Choi MJ 

PROVIDER: S-EPMC12749089 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature