Network-specific corpus callosum aging and age-moderated cognitive associations using tract-to-region analysis.

ABSTRACT: The corpus callosum (CC), the brain's largest white matter commissure, undergoes significant age-related atrophy that varies across subregions. However, how network-specific callosal connections age and relate to cognitive performance remains poorly understood. We analyzed diffusion-weighted imaging data from 718 healthy adults (ages 36-100 years) from the Human Connectome Project-Aging dataset. Using a tract-to-region approach, we quantified CC tract density within seven canonical functional networks. Cubic polynomial models examined network-specific aging trajectories, while correlation and moderation analyses investigated relationships with cognitive and motor performance across age groups. Network-specific CC tract densities showed distinct aging patterns. Somatomotor and Default Mode

SUBMITTER: Aarabi MH 

PROVIDER: S-EPMC12749135 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature