In Silico and in vitro Characterization of <i>Lactobacillus acidophilus</i> Bacteriocins as ROR-1-Targeted Therapeutics in Breast Cancer.

ABSTRACT:

Background

The human microbiota plays a crucial role in maintaining host health and is involved in various illnesses, including cancer. The intestinal microbiota has been identified as a factor in the development of colorectal carcinoma and breast cancer (BC).

Objectives

This study investigated the anticancer properties of bacteriocins produced by Lactobacillus acidophilus, specifically their interaction with receptor tyrosine kinase-like orphan receptor 1 (ROR-1), a protein involved in aggressive BC subtypes.

Methods

Employing sophisticated computational methodologies, encompassing molecular docking and molecular dynamics (MD) simulations, this research elucidated the dynamic interactions and binding strengths of four distinct bacteriocins - Acidocin A, Acidoc

SUBMITTER: Soheili S 

PROVIDER: S-EPMC12749213 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature