The kinases Hsl101 and Urk1 regulate metabolism of Cryptococcus neoformans.

ABSTRACT: Cryptococcus neoformans is a significant human fungal pathogen, particularly concerning for immunocompromised individuals. Key kinases, Hsl101 and Urk1, are critical for crossing the blood-brain barrier, although the specific mechanisms by which they do so remain undefined. In this study, we systematically investigate the impact of HSL101 or URK1 deletion on the proteomic and metabolomic profiles of C. neoformans. By generating a deletion mutant for HSL101, we observed profound alterations in the expression levels of 366 proteins and 421 metabolites, highlighting significant disruptions in key biological processes, such as oxidative phosphorylation and ATP synthesis, which are vital for energy production in the cell. Similarly, the deletion of URK1 resulted in significant changes in the ex

SUBMITTER: Ma Y 

PROVIDER: S-EPMC12749253 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature