Biomarkers of glycolysis and the tricarboxylic acid (TCA) cycle in youth with and without obesity.

ABSTRACT: Given the rising prevalence of childhood obesity, it is critical to understand the metabolic consequences of excess adiposity in youth. In particular, investigating alterations in glycolysis and the tricarboxylic acid (TCA) cycle in youth with obesity is essential for elucidating the underlying mechanisms contributing to metabolic dysregulation in this population. Forty-eight adolescents and young adults aged 15-24 years had plasma obtained after a 12-hour fasting to measure levels of glucose, insulin, and TCA cycle intermediates: pyruvate, lactate, fumarate, malate, α-ketoglutarate, cis/trans aconitate, and isocitrate. Additionally, participants underwent an assessment of liver proton-density fat fraction (PDFF) and a 3-hour oral glucose tolerance test (OGTT). Nineteen youth without obesi

SUBMITTER: Refugjati E 

PROVIDER: S-EPMC12749259 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature