Photocatalytic generation of amidine carbon radicals for aminodihydroquinoline synthesis.

ABSTRACT: Amidines are ubiquitous in medicines and natural products. However, robust synthetic access to a broad spectrum of diverse analogues remains challenging due to the intrinsic limitations of the two-electron (2e) pathway. To overcome these synthetic constraints, we seek to develop a variant that generates amidine carbon radical as a common chemical synthon based on a one-electron (1e) pathway, remodeling retro-synthetical analysis for amidine-containing compounds. Herein, we present a mild, modular, and practical photocatalytic system tailored for assembling the highly privileged amidine pharmacophore. By ingeniously combining thiourea with PPh₃, an amidine carbon radical is generated. This radical species can be efficiently coupled with a wide array of electron-deficient alkenes,

SUBMITTER: Yao X 

PROVIDER: S-EPMC12749265 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature