Multi-ancestry investigation of the genomics of erectile dysfunction.

ABSTRACT: Erectile dysfunction is attributable to numerous biological and psychological issues, and its prevalence increases with age. We conducted genome-wide association studies of erectile dysfunction in AllofUs subjects of European and African ancestry, then meta-analyzed our findings with published datasets [N_European = 913,194 (136,867 cases); N_African = 125,315 (51,599 cases)]. We identified 40 independent variants in Europeans, two in Africans, and 51 cross-ancestry. In all analyses, the strongest effect variants mapped to a non-coding region known to regulate SIM1, previously associated with erectile dysfunction: rs78677597 (Europeans) (p = 5.32 × 10^-139), and rs17185536 (Africans (p = 1.17 × 10^-9) and cross-ancestry (p = 5.3 × 10^-138))

SUBMITTER: Bright U 

PROVIDER: S-EPMC12749275 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature