LRP12 promotes gastric cancer progression through AKT/mTOR signaling and M2 macrophage-mediated immunosuppression.

ABSTRACT: Tumor-associated inflammation and macrophage polarization drive gastric cancer (GC) progression. We aimed to identify inflammation-related biomarkers that predict prognosis and modulate the tumor immune microenvironment, focusing on LDL receptor-related protein 12 (LRP12). We integrated public datasets with an in-house cohort to build an immune-related prognostic model based on inflammatory response-related genes (IRRGs) and to nominate candidate genes. Single-cell transcriptomics were used to map cell-type enrichment. Key findings were validated by multiplex immunofluorescence/immunohistochemistry, LRP12 overexpression and knockdown in GC cell lines, in vitro proliferation and invasion assays, western blotting for signaling pathways, and xenograft models. LRP12 was identified as a differe

SUBMITTER: Wang Y 

PROVIDER: S-EPMC12749278 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature