Construction of an early diagnostic model for pulmonary hypertension based on aging-related signature genes and identification of potential therapeutic targets.

ABSTRACT: Pulmonary hypertension (PH) is a progressive cardiopulmonary disorder. It features elevated pulmonary arterial pressure, which leads to right ventricular failure and increased mortality. PH's insidious nature, with no specific clinical symptoms, hinders early diagnosis. Recent investigations have implicated vascular cell senescence in the pathogenesis of PH; however, the identification of early diagnostic biomarkers and the development of senescence-targeted therapeutics remain areas of unmet need.In this study, an integrative transcriptomic analysis of multiple datasets was undertaken to delineate differentially expressed senescence-related genes (DESRGs). Feature genes were selected via the implementation of LASSO regression, random forest, and support vector machine algorithms. Subseque

SUBMITTER: Wang M 

PROVIDER: S-EPMC12749332 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature