Human cerebrospinal fluid net flow enhanced by respiration during the awake state.

ABSTRACT: Cerebrospinal fluid dynamics play a crucial role in maintaining brain homeostasis by delivering nutrients, transmitting immune signals, and clearing waste products. While cardiac activity primarily drives the pulsatile movement of cerebrospinal fluid, respiration has been shown to facilitate low-frequency oscillations and contribute to bulk flow. Recent studies suggest that enhancing respiratory function may be an effective intervention to modulate cerebrospinal fluid dynamics. This study included 20 individuals with long-term formal training in Seokmun Hoheup, a lower belly-centered breathing practice (mean ± SD age, 58.1 ± 17.3 years; 8 females), and 25 controls with no formal long-term breathing practice (mean ± SD age, 49.2 ± 20.2 years; 12 females). All underwent real-time velocity-en

SUBMITTER: Lim S 

PROVIDER: S-EPMC12749403 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature