A single-dose mRNA vaccine protects mice from lethal Crimean-Congo hemorrhagic fever virus infection.

ABSTRACT: Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne virus of the Orthonairovirus genus, Nairoviridae family, that causes severe febrile hemorrhagic disease in humans with a case fatality rate ranging from approximately 3-30%. This zoonotic pathogen is distributed across a broad geographic area spanning Asia, Europe, and Africa. Despite its significant public health threat and outbreak potential, no licensed vaccines are available. In this study, we developed and systematically assessed the immunogenicity and protective efficacy of mRNA vaccines encoding either CCHFV nucleoprotein (NP) or glycoprotein precursor (GPC) in mouse models. Vaccination with the NP-encoding mRNA alone provided complete protection against lethal cross-genotype CCHFV challenge. Moreover, combined vaccinatio

SUBMITTER: Rao J 

PROVIDER: S-EPMC12749442 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature