Multiscale chiral zeros in biomolecules.

ABSTRACT: Although chirality-mirror asymmetry-underpins biomolecular interactions, difficulties in quantifying it have long obscured insight into the precise role it plays in these interactions. Two standard chirality measures are the pseudoscalar Osipov-Pickup-Dunmur (OPD) index, which yields an asymmetry index with a sign, and the Hausdorff Chirality Measure (HCM), which yields only a magnitude. Theoretical arguments have shown that OPD is expected to have "chiral zeros," which occur when a chiral object is incorrectly assigned a chirality index value of zero. However, their existence remains theoretical and their abundance in real (bio)molecules has not been studied. We examined the differences between OPD and HCM in four different biological systems representing several different scales of chira

SUBMITTER: Moudgal N 

PROVIDER: S-EPMC12749453 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature