Association of blood miR-15a, miR-146a and miR-200b levels with stages of diabetic retinopathy.

ABSTRACT: Diabetic retinopathy (DR) is a serious complication of diabetes mellitus (DM). MicroRNAs (miRNAs) play crucial roles in DR pathogenesis, but their expression patterns across different DR stages remain unclear. To investigate the expression levels of hsa-miR-200b-5p, hsa-miR-146a-5p, and hsa-miR-15a-5p in the blood of patients in different stages of diabetic retinopathy. The research involved a sample size of 92 patients who had been diagnosed with type 2 diabetes. These patients were classified into three distinct groups: 50 patients with proliferative diabetic retinopathy (PDR), 30 patients with non-proliferative diabetic retinopathy (NPDR), and 12 patients with type 2 diabetes mellitus without retinopathy (DM) as a control group. The extraction of total RNA from whole blood samples was f

SUBMITTER: Yesharim L 

PROVIDER: S-EPMC12749463 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature