High-throughput in vitro screening and in silico analysis for Zika virus inhibitor identification.

ABSTRACT: Zika Virus (ZIKV) is a mosquito-borne virus that can cause serious health problems, including birth defects and neurological complications. Unfortunately, there are no antivirals currently approved for its treatments. In this study, we tested a library of 348 chemical compounds to find potential candidates that could block ZIKV infection. Seven compounds showed strong antiviral activity in laboratory experiments. Among them, Cephalotaxine, Docusate Sodium, and Saikosaponin B2 were the most effective. However, Docusate Sodium may pose safety risks at higher doses, and Saikosaponin B2 has poor solubility, which could limit its use as a drug. To better understand how these compounds work, molecular docking was employed to predict interactions between the active compounds and two important ZIK

SUBMITTER: Batool S 

PROVIDER: S-EPMC12749539 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature