Aldehyde Dehydrogenase 2 Gene Polymorphism and Alcohol Consumption Are Associated With Nephrolithiasis in a Chinese Population.

ABSTRACT:

Background

Nephrolithiasis is a common urological disorder and has become a significant global public health issue. Aldehyde dehydrogenase 2 (ALDH2), an important endogenous antioxidant enzyme involved in alcohol metabolism, has been shown to exert protective effects in various diseases. However, the specific role of ALDH2 gene polymorphisms in kidney stone formation, particularly in relation to alcohol consumption, remains poorly understood.

Methods

In this study, 979 nephrolithiasis patients and 1,009 healthy controls, matched for sex, age, and ethnicity, were enrolled. Genotyping of single nucleotide polymorphisms (SNPs) was performed, and a nephrolithiasis mouse model with Aldh2 deficiency was established to assess the susceptibility to kidney stone formation under Aldh2

SUBMITTER: Liu T 

PROVIDER: S-EPMC12749570 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature