Tumor necrosis associates with aggressive breast cancer features, increased hypoxia signaling and reduced patient survival.

ABSTRACT: In the growing tumor, hypoxia may lead to tumor necrosis which is associated with more aggressive tumor features and reduced patient survival. However, there are shortcomings in our understanding of biological features and clinical significance linked to tumor necrosis. We therefore analyzed transcriptome mRNA expression profiles from primary breast tumors from TCGA and METABRIC (n = 2289) including TCGA mutational data (n = 409). We employed bioinformatics analysis and independent literature-based signatures for validation to identify alterations unique to necrosis. Necrosis was associated with aggressive tumor features and strongly predicted the basal-like breast cancer phenotype. Increased tumor cell proliferation, hypoxia, stemness, and epithelial-to-mesenchymal transition (EMT) were o

SUBMITTER: Syrtveit AA 

PROVIDER: S-EPMC12749603 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature