Biohybrid microvascular interponates with integrated elastin-like recombinamers - validation of stability and biomimetic elasticity in human vessels.

ABSTRACT: Autologous vein grafts remain the gold standard for microvascular interpositions in reconstructive maxillofacial surgery, despite their high failure rates and the additional operation site. Against this background, this ex vivo study investigates a novel biohybrid microvascular graft based on elastin-like recombinamers (ELRs). The biohybrid graft design consists of ELRs combined with the mechanical support of textile components. The compliance and pressure resistance of the developed grafts were evaluated and compared with human fresh cadaver vessels (radial artery). The ELRs biohybrid grafts were microsurgically anastomosed with human radial arteries, and were compared with human vein interposition grafts from the saphena vein. The ELRs grafts exhibited comparable and favorable compliance

SUBMITTER: Heitzer M 

PROVIDER: S-EPMC12749630 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature