Elevated lactate-to-albumin ratio predicts short- and long-term mortality in trauma and surgical intensive care patients: a retrospective MIMIC-IV cohort study.

ABSTRACT: The lactate-to-albumin ratio (LAR), as a composite biomarker of integrated metabolic stress and systemic inflammation, has demonstrated prognostic utility in critical illnesses like sepsis and acute pancreatitis. However, its role in surgical/trauma intensive care unit (SICU/TSICU) patients remains underexplored. This study aimed to investigate the relationship between LAR and mortality in SICU/TSICU patients. A retrospective cohort analysis was conducted using the MIMIC-IV database. Adult SICU/TSICU patients with lactate and albumin measurements within 24 h of admission were included. Exclusion criteria were: repeat ICU admissions, ICU stay < 24 h, and missing lactate or albumin data. Ultimately, 2,665 patients were categorized into quartiles based on LAR. Multivariable Cox regression, re

SUBMITTER: Song Z 

PROVIDER: S-EPMC12749639 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature