Stromal transcriptomics uncover LIF as a key effector in high tumor budding triple-negative breast cancer.

ABSTRACT: The tumor budding (TB) and fibroblast activation protein (FAP)-positive cancer-associated fibroblasts (CAFs) are associated with patient prognosis in triple-negative breast cancer (TNBC). However, the impact between TB and FAP-positive CAFs on TNBC progression remains poorly understood. This study seeks to investigate the transcriptomic profile of FAP-positive CAFs in high TB TNBC to identify CAFs-derived factors contributing to disease aggressiveness. The 170 formalin-fixed paraffin-embedded TNBC tissues were assessed for TB by pan-cytokeratin immunohistochemistry (IHC). Its clinicopathological correlations were examined through univariate and multivariate analyses, with overall survival (OS) evaluated using Kaplan-Meier analysis. CAFs whole transcriptomic profiles of 13 TNBCs was conduct

SUBMITTER: Phankeaw P 

PROVIDER: S-EPMC12749643 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature