Hsa_circ_0001818 regulates the function of macrophages in sepsis by inhibiting miR-17-3p, miR-433-3p, and miR-642a-5p.

ABSTRACT: Sepsis is a leading cause of death due to severe infections. Macrophages are important players in regulating the development of sepsis. Notably, hsa_circ_0001818 is highly expressed in the serum exosomes of sepsis patients and has shown potential as a diagnostic marker for the condition. However, its regulatory role in sepsis remains unclear. Here, we reported that hsa_circ_0001818 expression in macrophages is increased in sepsis. After hsa_circ_0001818 silencing, the apoptotic rate and release of inflammatory cytokines decreased, while phagocytic function of macrophages increased. In contrast, after hsa_circ_0001818 overexpression, the apoptotic rate and the release of inflammatory factors increased, whereas phagocytic function of macrophages decreased. In addition, mechanistic studies an

SUBMITTER: Tian C 

PROVIDER: S-EPMC12749644 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature