Clinically feasible liver tumour cell size measurement through histology-informed in vivo diffusion MRI.

ABSTRACT:

Background

Innovative diffusion Magnetic Resonance Imaging (MRI) models enable the non-invasive measurement of cancer biological properties in vivo. However, while cancers frequently spread to the liver, models tailored for liver application and easy to deploy in the clinic are still sought. We fill this gap by delivering a practical, clinically-viable framework for liver tumour diffusion imaging, informing its design through histology.

Methods

We compare MRI and histological data from mice and cancer patients, namely: MRI and hemaotxylin-eosin (HE) stains from N = 7 fixed mouse livers; MRI of N = 38 patients suffering from liver solid tumours, N = 18 of whom with HE biopsies. We study five diffusion models, ranking them according to a total MRI-histology correlation score.

SUBMITTER: Grussu F 

PROVIDER: S-EPMC12749696 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature