Near-infrared photobiomodulation stimulates viability and cartilage matrix synthesis in human chondrocytes.

ABSTRACT: Photobiomodulation (PBM) within red to near-infrared spectrum has been proposed as a method to restore articular cartilage injuries, due to its ability to modulate effectively chondrocyte activity, namely viability, proliferation and extracellular matrix synthesis. This in vitro study aimed to determine the most appropriate PBM dosage on human chondrocytes. Firstly, human chondrocytes were stimulated daily or every other day with light-emitting diodes (LEDs) at wavelengths of 600-940 nm and power densities of 4-17 mW/cm², in continuous or pulsed mode for up to 4 min with temperature monitored during stimulation. After 3 days, the PBM most effective protocols enhancing metabolic activity and proliferation were further applied for seven days to assess their effect on cartilage pro

SUBMITTER: Oliveira S 

PROVIDER: S-EPMC12749754 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature