Senescence-related gene signatures in Crohn's disease: integrating bulk and single-cell RNA sequencing analysis.

ABSTRACT: Crohn's disease (CD) is a chronic, relapsing inflammatory bowel disease (IBD). Recent studies have revealed that intestinal tissues of CD patients exhibit progeroid-like features, suggesting that cellular senescence may contribute to CD progression. However, the specific roles of senescence-related genes in CD and their impact on prognosis remain unclear. This study identified CD-associated senescence genes through differential expression analysis. Machine learning algorithms were employed to further screen for hub genes. Gene Set Enrichment Analysis (GSEA) was performed to explore the potential functions of these hub genes, and their association with immune cell infiltration was assessed using the CIBERSORT algorithm. Independent external datasets were utilized to validate the diagnostic

SUBMITTER: Luo X 

PROVIDER: S-EPMC12749775 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature