Stage-dependent patterns of cognitive network connectivity in early psychosis.

ABSTRACT: Cognitive impairments in early psychosis are common, yet prior studies have focused mainly on domain-specific deficits rather than inter-domain relationships. Analyzing cognitive network connectivity may uncover insights into early psychosis mechanisms. Cognitive functions were assessed from 2,518 participants, including 988 first-episode schizophrenia (FES), 767 clinical high-risk (CHR), and 763 healthy controls (HC), using the Chinese version of the Measurement and Treatment Research to Improve Cognition in Schizophrenia Consensus Cognitive Battery (MCCB). Results revealed a stage-dependent "dedifferentiation" pattern: mean inter-domain correlation increased from HC (0.28) to CHR (0.33) to FES (0.40). Confirmatory factor analysis revealed a common "g" factor across groups, with significa

SUBMITTER: Tang X 

PROVIDER: S-EPMC12749795 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature