Dual roles of USP1 in HELLS deubiquitination and SUMOylation drive EMT and FOLFOX-based chemoresistance.

ABSTRACT: Although the FOLFOX strategy has demonstrated benefits for tumor patients at advanced stages, chemoresistance remains a significant challenge to therapeutic efficacy. Thus, identifying strategies to overcome chemoresistance and enhance chemotherapy sensitivity is critical for optimizing HAIC-FOLFOX treatment. Comprehensive investigations of deubiquitinating enzymes (DUBs) across multiple bioinformatics cohorts and a local hepatocellular carcinoma (HCC) cohort identified ubiquitin-specific protease 1 (USP1) as a key regulator of HCC progression, correlating with poor survival outcomes. Functional assays demonstrated that USP1 overexpression promotes aggressive phenotypes in HCC cells, including enhanced proliferation, migration, and epithelial-mesenchymal transition (EMT), whereas USP1 inhi

SUBMITTER: Gao J 

PROVIDER: S-EPMC12749804 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature