Distinct immune cell dynamics associated with immune-related adverse events during combined chemoradiation and immune checkpoint inhibitor therapy.

ABSTRACT: Combining chemoradiotherapy with immunotherapy increases the risk of immune-related adverse events (irAEs), but the underlying mechanisms remain poorly understood. To address this, we conducted a longitudinal single-cell multi-omics analysis of patients with locally advanced cervical cancer. Here we show that the proportions of CD4⁺ and CD8⁺ terminally differentiated effector memory or effector T cells are elevated in patients with irAEs. Chemoradiotherapy reduces B cell clonality while increasing the abundance and somatic hypermutation frequencies of IgA⁺ and IgG⁺ B cells in irAE patients. In the myeloid compartment, combined treatment expands specific monocyte subclusters associated with irAEs. Spatial transcriptomics and immunofluorescence ana

SUBMITTER: Zhang L 

PROVIDER: S-EPMC12749808 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature