Remimazolam-induced anesthesia does not affect circadian rhythms significantly in mice.

ABSTRACT: Although inhalational general anesthesia affects mammalian circadian rhythms, which are generated through oscillations in expression of clock genes in the suprachiasmatic nucleus (SCN), the impact of intravenous benzodiazepine (BDZ)-induced general anesthesia is not well understood. We investigated the effects of remimazolam (RMZ), an ultra-short-acting BDZ that has recently gained widespread use in clinical anesthesia, on circadian rhythms and clock gene expression in the SCN in male C57BL/6J mice. Phase shifts in behavioral rest-activity circadian rhythms were quantitatively measured under constant dark conditions. No significant differences were detected among the interventions tested: continuous RMZ injection, bolus RMZ injection, and saline injection at different circadian times. Anal

SUBMITTER: Suzuki Y 

PROVIDER: S-EPMC12749832 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature