Efficacy and safety of insulin efsitora in type 2 diabetes: a meta-analysis of randomized controlled trials.

ABSTRACT:

Objective

This meta-analysis aimed to evaluate the efficacy and safety profiles of insulin efsitora in the treatment of type 2 diabetes (T2D).

Methods

We conducted a comprehensive systematic search across PubMed, the Cochrane Library, and Embase from database inception through September 11, 2025. The study included randomized controlled trials (RCTs) that directly compared insulin efsitora with once daily basal insulin in T2D patients. Primary outcomes assessed were changes in hemoglobin A1c (HbA1c) and body weight. Methodological quality and risk of bias were evaluated using the Cochrane Quality Assessment Tool. Data synthesis was performed using random-effects models to calculate risk ratios (RR) and mean differences (MD).

Results

The meta-analysis incorporated six

SUBMITTER: Liu Y 

PROVIDER: S-EPMC12749861 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature