MRI structural and functional axial asymmetry in the brain-first versus body-first subtypes of Parkinson's disease.

ABSTRACT: Parkinson's Disease (PD) with Rapid Eye Movement Sleep Behavior Disorder (RBD) occurred before (body-first) and after (brain-first) motor symptoms may exhibit different MRI features. We aimed to investigate the structural and functional MRI pattern differences between brain-first and body-first subtypes of PD. 23 body-first and 19 brain-first PD patients, along with 20 matched healthy controls (HC) were enrolled and underwent T1-weighted and resting-state functional magnetic resonance imaging (rs-fMRI) scans in NJ-dataset. We calculated and compared amplitude of low-frequency fluctuations (ALFF) and gray matter volume (GMV) across groups to identify differential brain regions, which were subsequently extracted in PPMI and OASIS3 datasets. These values were combined with clinical data for b

SUBMITTER: Shi J 

PROVIDER: S-EPMC12749918 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature