Distinct protein profiles in cord blood plasma of children with autism spectrum disorder.

ABSTRACT: Autism spectrum disorder (ASD) has a genetic origin in approximately 30% of cases, while the remaining causes are primarily linked to epigenetic and non-genetic factors. This study aims to identify potential non-genetic causes contributing to ASD by investigating the underlying cellular mechanisms through proteomic analysis. Extracellular vesicles (EVs) mediate cellular communication and are linked to brain development disorders. Here, we utilize mass-spectrometry-based proteomic analysis of EVs derived from umbilical cord blood plasma collected from 30 children diagnosed with non-syndromic ASD and 30 neurotypical controls. The analysis identified 565 proteins with significantly different expression levels, most of which were more abundant in the ASD group. Notably, the protein expression

SUBMITTER: Philosoph LK 

PROVIDER: S-EPMC12749933 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature